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Exercise Distributed across Day and Night Does Not Alter Circadian Period in Humans

Division of Sleep Medicine, Department of Medicine, Brigham & Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA, swcain{at}rics.bwh.harvard.edu

David W. Rimmer

Division of Sleep Medicine, Department of Medicine, Brigham & Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA

Jeanne F. Duffy

Division of Sleep Medicine, Department of Medicine, Brigham & Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA

Charles A. Czeisler

Division of Sleep Medicine, Department of Medicine, Brigham & Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA

In rodents, increased activity due to running-wheel access is associated with a change in observed circadian period. In humans, exposure to exercise has failed to demonstrate similar effects on period. Methodological issues with prior studies such as light exposure during exercise, length of study, and method of measuring period confounded those evaluations of the effect of exercise on period in humans. In the present experiment, the authors examined the effect of exercise on period in 8 subjects using a 44-day within-subjects inpatient study. They used a 20-h forced desynchrony protocol, in which subjects were exposed to exercise across circadian phases under dim light conditions. Exercise consisted of three 45-min sessions per wake period on an ergometer. Target exercise intensity was ~65% of maximal heart rate. Intrinsic circadian period was measured using both core body temperature and hourly plasma melatonin samples. Consistent with previous reports, the authors find no effect of exercise on endogenous circadian period as measured by either core body temperature or melatonin. Exercise distributed across biological day and night does not appear to affect circadian period.

Key Words: activity • tau • nonphotic • parametric • ergometer • core body temperature • melatonin • behavioral feedback

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Journal of Biological Rhythms, Vol. 22, No. 6, 534-541 (2007)
DOI: 10.1177/0748730407306884


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cain, S. W. Articles by Czeisler, C. A. Search for Related Content PubMed PubMed Citation Articles by Cain, S. W. Articles by Czeisler, C. A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Exercise for Children Exercise and Physical Fitness Social Bookmarking                         What's this?