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Journal of Biological Rhythms
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Effects of Food Deprivation on Locomotor Activity, Plasma Glucose, and Circadian Clock Resetting in Syrian Hamsters

Ralph E. Mistlberger

Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada, mistlber{at}sfu.ca

Ian C. Webb

Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada

Melissa M. Simon

Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada

Dierdre Tse

Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada

Cathy Su

Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada

Circadian rhythms in Syrian hamsters can be phase advanced by activity or arousal stimulated during the daily rest phase ("subjective day"). A widely used method for stimulating activity is confinement to a novel wheel. Some hamsters decline to run, and some procedures may reduce the probability of running. The authors evaluated food deprivation (FD) as a method to promote running. Given evidence that perturbations of cell metabolism or glucose availability may affect circadian clock function in some tissues or species, they also assessed the effects of FD on free-running circadian phase, resetting responses to photic and nonphotic stimuli and plasma glucose. In constant light, a 27-h fast significantly increased running in a novel wheel and marginally increased the average size of resulting phase shifts. FD, without novel wheel confinement, was associated with some very large phase shifts or disruption of rhythmicity in hamsters that spontaneously ran in their home wheels during the subjective day. Hamsters that ran only during the usual active phase (subjective night) or that were prevented from running did not exhibit phase shifts, despite refeeding in the mid-subjective day. Using an Aschoff Type II design for measuring shifts, a 27-h fast significantly increased the number of hamsters that ran continuously when confined to a novel wheel but did not affect the dose-response relation between the amount of running and the size of the resulting shift. A day of fasting also did not affect the size of phase delay or advance shifts to 30-min light pulses in the subjective night. Plasma glucose was markedly reduced by wheel running in combination with fasting but was increased by running in nonfasted hamsters. These results establish FD as a useful tool for stimulating activity in home cage or novel wheels and indicate that in Syrian hamsters, significant alterations in glucose availability, associated with running, fasting, and refeeding, have surprisingly little effect on circadian pacemaker function.

Key Words: circadian rhythms • metabolism • phase shifts • exercise • light pulses

References

Journal of Biological Rhythms, Vol. 21, No. 1, 33-44 (2006)
DOI: 10.1177/0748730405282877
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
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Right arrow Citation Map
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mistlberger, R. E.
Right arrow Articles by Su, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mistlberger, R. E.
Right arrow Articles by Su, C.
Social Bookmarking
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What's this?