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The Association between the Nocturnal Sleep Gate and Nocturnal Onset of Urinary 6-Sulfatoxymelatonin

Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

A. Shlitner

Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

P. Lavie

Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

The present study investigated the relationship between the time of nocturnal onset of urinary 6-sulfatoxymelatonin (aMT6s) secretion, and the timing of the steepest increase in nocturnal sleepiness ("sleep gate"), as determined by an ultrashort sleep-wake cycle test (7 min sleep, 13 min wake). Twenty-nine men (mean age 23.8 ± 2.7 years) participated. The ultrashort sleep-wake paradigm started at 0700 hr after a night of sleep deprivation and continued for 24 hr until 0700 hr the next day. Electrophysiological recordings were carried out during the 7-min sleep trials, which were then scored conventionally for sleep stages. Urinary aMT6s was measured every 2 hr. The results showed that the timing of the sleep gate was significantly correlated with the onset of aMT6s secretion. These results are discussed in light of the possible role of melatonin in sleep-wake regulation.

Key Words: sleep gate • sleep propensity • aMT6s • ultrashort sleep-wake cycle test • young adults

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