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Light-Induced Phase Shifts and Fos Expression in the Hamster Circadian System: The Effects of Anesthetics

NSF Center for Biological Timing, Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903

Claire M. Kaufman

NSF Center for Biological Timing, Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903

Michael Menaker

NSF Center for Biological Timing, Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903

Martin R. Ralph

Department of Psychology, University of Toronto, Toronto, Ontario, MSS 1A1, Canada

In the present study, we examined the effect of administration of anesthetics on light-induced phase shifts of the circadian system. This information is of critical importance, because many studies of light input to the mammalian suprachiasmatic nucleus (SCN) have been performed on anesthetized animals. We found that light-induced phase shifts were blocked by all drugs used at anesthetic doses. We then determined the effect of two of these agents on light induction of Fos-like immunoreactivity in the SCN. We found that the administration of sodium pentobarbital prevented light induction of Fos expression in the SCN, whereas the administration of urethane did not. These results raise cautions about the use of anesthetized animals to answer questions about the photic regulation of neuronal activity in the SCN.

Key Words: anesthetics • circadian • Fos • photic • suprachiasmatic nucleus

Journal of Biological Rhythms, Vol. 8, No. 3, 179-188 (1993)
DOI: 10.1177/074873049300800301


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