|
Sign In to gain access to subscriptions and/or personal tools.
|
Serotonin and the Mammalian Circadian System: II. Phase-Shifting Rat Behavioral Rhythms with Serotonergic Agonists
Dale M. Edgar
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
Joseph D. Miller
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Department of Biological Sciences, Stanford University, Stanford, California 94305
Rebecca A. Prosser
Department of Biological Sciences, Stanford University, Stanford, California 94305
Robin R. Dean
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
William C. Dement
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
The suprachiasmatic nuclei (SCN) receive primary afferents from the median and dorsal raphe, but the role of these projections in circadian timekeeping is poorly understood. Studies of the SCN in vitro suggest that quipazine, a general serotonin (5-HT) receptor agonist, can produce circadian time-dependent phase advances and phase delays in circadian rhythms of neuronal activity. The present study addresses whether quipazine and the selective 5-HT 1A receptor agonist 8-OH-DPAT are similarly effective in vivo. Drinking and wheel-running patterns of male Wistar rats individually housed in constant darkness were monitored before and after subcutaneous administration of quipazine (5-10 mg/kg) at either circadian time (CT) 6 or CT 18, with and without running wheels available. Dose-dependent phase advances (20-180 min) were produced at CT 6. Significant phase shifts were not observed at CT 18. CT 6 quipazine-treated animals also showed a sustained and significant shortening of rhythm period ( ) following treatment (-0.28 hr; p < 0.002). shortening was inconsistently observed in CT 18 quipazine-treated rats. Neither quipazine-induced phase shifts nor effects were dependent on wheel-running activity per se. 8-OH-DPAT delivered via intracerebral ventricular treatment into the third ventricle (5 µl at 100 µM in saline) produced slightly smaller phase advances (20-90 min) at CT 6, but did not produce phase delays at CT 18 or changes in . These findings support in vitro evidence that 5-HT-ergic agonists can phase-shift the circadian pacemaker.
Key Words: circadian rhythm • serotonin • phase-shift • period • quipazine • 8-OH-DPAT • rat
Journal of Biological Rhythms, Vol. 8, No. 1,
17-31 (1993)
DOI: 10.1177/074873049300800102
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. S. Menet, P. Vuillez, M. Saboureau, and P. Pevet
Inhibition of hibernation by exercise is not affected by intergeniculate leaflets lesion in hamsters
Am J Physiol Regulatory Integrative Comp Physiol,
September 1, 2003;
285(3):
R690 - R700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Glass, G. H. Grossman, L. Farnbauch, and L. DiNardo
Midbrain Raphe Modulation of Nonphotic Circadian Clock Resetting and 5-HT Release in the Mammalian Suprachiasmatic Nucleus
J. Neurosci.,
August 20, 2003;
23(20):
7451 - 7460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Antle, M. D. Ogilvie, G. E. Pickard, and R. E. Mistlberger
Response of the Mouse Circadian System to Serotonin 1A/2/7 Agonists in vivo: Surprisingly Little
J Biol Rhythms,
April 1, 2003;
18(2):
145 - 158.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Salazar-Juarez, C. Escobar, and R. Aguilar-Roblero
Anterior paraventricular thalamus modulates light-induced phase shifts in circadian rhythmicity in rats
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2002;
283(4):
R897 - R904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jovanovska and R. A. Prosser
Translational and Transcriptional Inhibitors Block Serotonergic Phase Advances of the Suprachiasmatic Nucleus Circadian Pacemaker In Vitro
J Biol Rhythms,
April 1, 2002;
17(2):
137 - 146.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. A. Prosser
Glutamate Blocks Serotonergic Phase Advances of the Mammalian Circadian Pacemaker through AMPA and NMDA Receptors
J. Neurosci.,
October 1, 2001;
21(19):
7815 - 7822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Ehlen, G. H. Grossman, and J. D. Glass
In Vivo Resetting of the Hamster Circadian Clock by 5-HT7 Receptors in the Suprachiasmatic Nucleus
J. Neurosci.,
July 15, 2001;
21(14):
5351 - 5357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Stepien and D. J. Kennaway
Phase Response Relationships between Light Pulses and the Melatonin Rhythm in Rats
J Biol Rhythms,
June 1, 2001;
16(3):
234 - 242.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. N. Smith, P. J. Sollars, F. E. Dudek, and G. E. Pickard
Serotonergic Modulation of Retinal Input to the Mouse Suprachiasmatic Nucleus Mediated by 5-HT1B and 5-HT7 Receptors
J Biol Rhythms,
February 1, 2001;
16(1):
25 - 38.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Horikawa, S.-i. Yokota, K. Fuji, M. Akiyama, T. Moriya, H. Okamura, and S. Shibata
Nonphotic Entrainment by 5-HT1A/7 Receptor Agonists Accompanied by Reduced Per1 and Per2 mRNA Levels in the Suprachiasmatic Nuclei
J. Neurosci.,
August 1, 2000;
20(15):
5867 - 5873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Flett and C. S. Colwell
Serotonin Modulation of Calcium Transients in Cells in the Suprachiasmatic Nucleus
J Biol Rhythms,
October 1, 1999;
14(5):
354 - 363.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. E. Quintero and D. G. McMahon
Serotonin Modulates Glutamate Responses in Isolated Suprachiasmatic Nucleus Neurons
J Neurophysiol,
August 1, 1999;
82(2):
533 - 539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Poncet, J.-M. Pequignot, J.-M. Cottet-Emard, Y. Dalmaz, and L. Denoroy
Altered daily rhythms of brain and pituitary indolamines and neuropeptides in long-term hypoxic rats
Am J Physiol Regulatory Integrative Comp Physiol,
July 1, 1999;
277(1):
R66 - R75.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Dudley, L. A. Dinardo, and J. D. Glass
In Vivo Assessment of the Midbrain Raphe Nuclear Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus
J Neurophysiol,
April 1, 1999;
81(4):
1469 - 1477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kohler, A. Kalkowski, and F. Wollnik
Serotonin Agonist Quipazine Induces Photic-Like Phase Shifts of the Circadian Activity Rhythm and c-Fos Expression in the Rat Suprachiasmatic Nucleus
J Biol Rhythms,
April 1, 1999;
14(2):
131 - 140.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. L. Meyer-Bernstein and L. P. Morin
Destruction of Serotonergic Neurons in the Median Raphe Nucleus Blocks Circadian Rhythm Phase Shifts to Triazolam but Not to Novel Wheel Access
J Biol Rhythms,
December 1, 1998;
13(6):
494 - 505.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Challet, K. Scarbrough, P. D. Penev, and F. W. Turek
Roles of Suprachiasmatic Nuclei and Intergeniculate Leaflets in Mediating the Phase-Shifting Effects of a Serotonergic Agonist and Their Photic Modulation during Subjective Day
J Biol Rhythms,
October 1, 1998;
13(5):
410 - 421.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Kohler and F. Wollnik
Locking and Unlocking of Running Wheel Affects Circadian Period Stability Differently in Three Inbred Strains of Rats
J Biol Rhythms,
August 1, 1998;
13(4):
296 - 304.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. E. Dudley, L. A. DiNardo, and J. D. Glass
Endogenous Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus
J. Neurosci.,
July 1, 1998;
18(13):
5045 - 5052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kalsbeek, J. J. van Heerikhuize, J. Wortel, and R. M. Buijs
Restricted Daytime Feeding Modifies Suprachiasmatic Nucleus Vasopressin Release in Rats
J Biol Rhythms,
February 1, 1998;
13(1):
18 - 29.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. G. Marchant, N. V. Watson, and R. E. Mistlberger
Both Neuropeptide Y and Serotonin Are Necessary for Entrainment of Circadian Rhythms in Mice by Daily Treadmill Running Schedules
J. Neurosci.,
October 15, 1997;
17(20):
7974 - 7987.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Challet, P. Pevet, and A. Malan
Lesion of the Serotonergic Terminals in the Suprachiasmatic Nuclei Limits the Phase Advance of Body Temperature Rhythm in Food-Restricted Rats Fed during Daytime
J Biol Rhythms,
June 1, 1997;
12(3):
235 - 244.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. J. W. Van Someren, C. Lijzenga, M. Mirmiran, and D. F. Swaab
Long-Term Fitness Training Improves the Circadian Rest-Activity Rhythm in Healthy Elderly Males
J Biol Rhythms,
April 1, 1997;
12(2):
146 - 156.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Hannibal, J. M. Ding, D. Chen, J. Fahrenkrug, P. J. Larsen, M. U. Gillette, and J. D. Mikkelsen
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock
J. Neurosci.,
April 1, 1997;
17(7):
2637 - 2644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Gillespie, K. L. Huhman, T. O. Babagbemi, and H. E. Albers
Bicuculline Increases and Muscimol Reduces the Phase-Delaying Effects of Light and VIP/PHI/GRP in the Suprachiasmatic Region
J Biol Rhythms,
June 1, 1996;
11(2):
137 - 144.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S.-i. Matsumoto, J. Basil, A. E. Jetton, M. N. Lehman, and E. L. Bittman
Regulation of the Phase and Period of Circadian Rhythms Restored by Suprachiasmatic Transplants
J Biol Rhythms,
June 1, 1996;
11(2):
145 - 162.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.D. Glass, M. Selim, G. Srkalovic, and M.A. Rea
Tryptophan Loading Modulates Light-Induced Responses in the Mammalian Circadian System
J Biol Rhythms,
March 1, 1995;
10(1):
80 - 90.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Shibata and R. Y. Moore
Calmodulin Inhibitors Produce Phase Shifts of Circadian Rhythms In Vivo and In Vitro
J Biol Rhythms,
March 1, 1994;
9(1):
27 - 41.
[Abstract]
[PDF]
|
|
|
|
|
