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Journal of Biological Rhythms
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Combined Effects on the Circadian Clock of Agents with Different Phase Response Curves: Phase-Shifting Effects of Triazolam and Light

Janet E. Joy

Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208

Although light provides the primary signal for the entrainment of circadian pacemakers, a number of endogenous substances and pharmacological agents are also capable of resetting circadian pacemakers. Very little is known about the combined effects of photic and nonphotic agents on clock functions. We conducted a "double-pulse" experiment, in which two discrete stimuli are presented at different times within a single circadian cycle, to determine the combined effects of a 1-hr light pulse and injections of a benzodiazepine, triazolam, on the circadian rhythm of activity in the golden hamster.

Key Words: phase response curves • circadian pacemaker • triazolam • light • double-pulse

Journal of Biological Rhythms, Vol. 7, No. 1, 51-63 (1992)
DOI: 10.1177/074873049200700105
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