|
Sign In to gain access to subscriptions and/or personal tools.
|
Activity Feedback to the Mammalian Circadian Pacemaker: Influence on Observed Measures of Rhythm Period Length
Dale M. Edgar
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305
Connie E. Martin
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305
William C. Dement
Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305
In the mouse, activity is precisely timed by the circadian clock and is normally most intense in the early subjective night. Since vigorous activity (e.g., wheel running) is thought to induce phase shifts in rodents, the temporal placement of daily exercise/activity could be a determinant of observed circadian rhythm period. The relationship between spontaneous running-wheel activity and the circadian period of free-running rhythms was studied to assess this possibility. With ad libitum access to a running wheel, mice exhibited a free-running period ( ) of 23.43 ± 0.08 hr (mean ± SEM). When running wheels were locked, increased (23.88 ± 0.04 hr, p < 0.03), and restoration of ad libitum wheel running again produced a shorter period ( = 23.56 ± 0.06 hr, p < 0.05). A survey of free- running activity patterns in a population of 100 mice revealed a significant correlation between the observed circadian period and the time of day in which spontaneous wheel running occurred (r = 0.7314, p < 0.0001). Significantly shorter periods were observed when running was concentrated at the beginning of the subjective night ( = 23.23 ± 0.04), and longer periods were observed if mice ran late in the subjective night ( = 23.89 ± 0.04), F (1, 99) = 34.96, p < 0.0001. It was previously believed that the period of the circadian clock was primarily responsive to externally imposed tonic or phasic events. Systematic influences of spontaneous exercise on demonstrate that physiological and/or behavioral determinants of circadian timekeeping exist as well.
Journal of Biological Rhythms, Vol. 6, No. 3,
185-199 (1991)
DOI: 10.1177/074873049100600301
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
P. M. Fuller and C. A. Fuller
Genetic Evidence for a Neurovestibular Influence on the Mammalian Circadian Pacemaker
J Biol Rhythms,
June 1, 2006;
21(3):
177 - 184.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. J. Chiesa, M. Angles-Pujolras, A. Diez-Noguera, and T. Cambras
Activity rhythm of golden hamster (Mesocricetus auratus) can be entrained to a 19-h light-dark cycle
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2005;
289(4):
R998 - R1005.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Moretti, J. A. Bouwknecht, R. Teague, R. Paylor, and H. Y. Zoghbi
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
Hum. Mol. Genet.,
January 15, 2005;
14(2):
205 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Takahashi
Finding New Clock Components: Past and Future
J Biol Rhythms,
October 1, 2004;
19(5):
339 - 347.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. K. Barger, K. P. Wright Jr., R. J. Hughes, and C. A. Czeisler
Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
Am J Physiol Regulatory Integrative Comp Physiol,
June 1, 2004;
286(6):
R1077 - R1084.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Hofstetter, J. A. Trofatter, J. I. Nurnberger, K. L. Kernek, and A. R. Mayeda
New Quantitative Trait Loci for the Genetic Variance in Circadian Period of Locomotor Activity between Inbred Strains of Mice
J Biol Rhythms,
December 1, 2003;
18(6):
450 - 462.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Koteja Jr., J. G. Swallow, P. A. Carter, and T. Garland
Different Effects of Intensity and Duration of Locomotor Activity on Circadian Period
J Biol Rhythms,
December 1, 2003;
18(6):
491 - 501.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Sollars, M. D. Ogilvie, M. A. Rea, and G. E. Pickard
5-HT1B Receptor Knockout Mice Exhibit an Enhanced Response to Constant Light
J Biol Rhythms,
October 1, 2002;
17(5):
428 - 437.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. E. Larkin, P. Franken, and H. C. Heller
Loss of circadian organization of sleep and wakefulness during hibernation
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 2002;
282(4):
R1086 - R1095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Shimomura, S. S. Low-Zeddies, D. P. King, T. D.L. Steeves, A. Whiteley, J. Kushla, P. D. Zemenides, A. Lin, M. H. Vitaterna, G. A. Churchill, et al.
Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice
Genome Res.,
June 1, 2001;
11(6):
959 - 980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. H. Kas and D. M. Edgar
Scheduled Voluntary Wheel Running Activity Modulates Free-Running Circadian Body Temperature Rhythms in Octodon degus
J Biol Rhythms,
February 1, 2001;
16(1):
66 - 75.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. R. Kendall, A. J. Lewy, and R. L. Sack
Effects of Aging on the Intrinsic Circadian Period of Totally Blind Humans
J Biol Rhythms,
February 1, 2001;
16(1):
87 - 95.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. E. Mistlberger and M. M. Holmes
Behavioral feedback regulation of circadian rhythm phase angle in light-dark entrained mice
Am J Physiol Regulatory Integrative Comp Physiol,
September 1, 2000;
279(3):
R813 - R821.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Franken, L. Lopez-Molina, L. Marcacci, U. Schibler, and M. Tafti
The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity
J. Neurosci.,
January 15, 2000;
20(2):
617 - 625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Hut, N. Mrosovsky, and S. Daan
Nonphotic Entrainment in a Diurnal Mammal, the European Ground Squirrel (Spermophilus citellus)
J Biol Rhythms,
October 1, 1999;
14(5):
409 - 420.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. B. Klerman, Y. Lee, C. A. Czeisler, and R. E. Kronauer
Linear Demasking Techniques Are Unreliable for Estimating the Circadian Phase of Ambulatory Temperature Data
J Biol Rhythms,
August 1, 1999;
14(4):
260 - 274.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. A. Czeisler, J. F. Duffy, T. L. Shanahan, E. N. Brown, J. F. Mitchell, D. W. Rimmer, J. M. Ronda, E. J. Silva, J. S. Allan, J. S. Emens, et al.
Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker
Science,
June 25, 1999;
284(5423):
2177 - 2181.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. Klante, K. Secci, M. Masson-Pevet, P. Pevet, B. Vivien-Roels, S. Steinlechner, and F. Wollnik
Interstrain differences in activity pattern, pineal function, and SCN melatonin receptor density of rats
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 1999;
276(4):
R1078 - R1086.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yamazaki, M. C. Kerbeshian, C. G. Hocker, G. D. Block, and M. Menaker
Rhythmic Properties of the Hamster Suprachiasmatic Nucleus In Vivo
J. Neurosci.,
December 15, 1998;
18(24):
10709 - 10723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. Davis and N. Viswanathan
Stability of circadian timing with age in Syrian hamsters
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 1998;
275(4):
R960 - R968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kohler and F. Wollnik
Locking and Unlocking of Running Wheel Affects Circadian Period Stability Differently in Three Inbred Strains of Rats
J Biol Rhythms,
August 1, 1998;
13(4):
296 - 304.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Lax, S. Zamora, and J. A. Madrid
Coupling effect of locomotor activity on the rat's circadian system
Am J Physiol Regulatory Integrative Comp Physiol,
August 1, 1998;
275(2):
R580 - R587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. S. Valentinuzzi, K. Scarbrough, J. S. Takahashi, and F. W. Turek
Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice
Am J Physiol Regulatory Integrative Comp Physiol,
December 1, 1997;
273(6):
R1957 - R1964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Freeman and B. D. Goldman
Evidence that the Circadian System Mediates Photoperiodic Nonresponsiveness in Siberian Hamsters: The Effect of Running Wheel Access on Photoperiodic Responsiveness
J Biol Rhythms,
April 1, 1997;
12(2):
100 - 109.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. J. W. Van Someren, C. Lijzenga, M. Mirmiran, and D. F. Swaab
Long-Term Fitness Training Improves the Circadian Rest-Activity Rhythm in Healthy Elderly Males
J Biol Rhythms,
April 1, 1997;
12(2):
146 - 156.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Meerlo, R.H. van den Hoofdakker, J.M. Koolhaas, and S. Daan
Stress-Induced Changes in Circadian Rhythms of Body Temperature and Activity in Rats Are not Caused by Pacemaker Changes
J Biol Rhythms,
February 1, 1997;
12(1):
80 - 92.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.-J. Dijk, Z. Boulos, C. I. Eastman, A. J. Lewy, S. S. Campbell, and M. Terman
Light Treatment for Sleep Disorders: Consensus Report: II. Basic Properties of Circadian Physiology and Sleep Regulation
J Biol Rhythms,
June 1, 1995;
10(2):
113 - 125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. P. Gerkema, S. Daan, M. Wilbrink, M. W. Hop, and F. van der Leest
Phase Control of Ultradian Feeding Rhythms in the Common Vole ( Microtus arvalis): The Roles of Light and the Circadian System
J Biol Rhythms,
July 1, 1993;
8(2):
151 - 171.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. M. Edgar, J. D. Miller, R. A. Prosser, R. R. Dean, and W. C. Dement
Serotonin and the Mammalian Circadian System: II. Phase-Shifting Rat Behavioral Rhythms with Serotonergic Agonists
J Biol Rhythms,
April 1, 1993;
8(1):
17 - 31.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Aschoff
On the Relationship between Motor Activity and the Sleep-Wake Cycle in Humans during Temporal Isolation
J Biol Rhythms,
April 1, 1993;
8(1):
33 - 46.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. R. Ralph and N. Mrosovsky
Behavioral Inhibition of Circadian Responses to Light
J Biol Rhythms,
December 1, 1992;
7(4):
353 - 359.
[Abstract]
[PDF]
|
|
|
|
|
