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Journal of Biological Rhythms
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Temporal Structure of In Vivo Adrenal Secretory Activity Estimated by Deconvolution Analysis

Johannes D. Veldhuis

Interdisciplinary Graduate Biophysics Program, Divison of Endocrinology and Metabolism, Department of Internal Medicine

Michael L. Johnson

Sections of Biomathematics and Interdisciplinary Graduate Biophysics Program, Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908

Ali Iranmanesh

Division of Endocrinology, Department of Medicine, Salem Veterans Administration Hospital, Salem Virginia 24153

German Lizarralde

Division of Endocrinology, Department of Medicine, Salem Veterans Administration Hospital, Salem Virginia 24153

Circadian and ultradian rhythms of plasma cortisol concentrations have been documented under physiological conditions in diverse animal species. Using a novel, biophysical convolution model to remove subject-specific metabolic clearance rates, we have now estimated spontaneous adrenal secretory events in vivo. The latter were characterized by prominent ultradian rhythms of discrete secretory bursts with periodicities averaging 32, 46, 76, and 130 min. These ultradian cortisol secretory rhythms represented a 17- to 240-fold larger fraction of circadian secretory variations than did cortisol concentration rhythms. We conclude that deconvolution analysis can unmask underlying ultradian rhythms in adrenal secretory activity in vivo.

Journal of Biological Rhythms, Vol. 5, No. 3, 247-255 (1990)
DOI: 10.1177/074873049000500306
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