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Journal of Biological Rhythms
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Cycloheximide Inhibits Light-Induced Phase Shifting of the Circadian Clock in Neurospora

Carl Hirschie Johnson

Department of Biology, Vanderbilt University, Box 1812, Station B, Nashville, Tennessee 37235

Hideaki Nakashima

Division of Chronobiology, National Institute for Basic Biology, Myodaijicho, Okazaki 444, Japan

Cycloheximide inhibits light-induced phase shifting of the circadian clock and protein synthesis in Neurospora. Light resetting is not inhibited in mutants whose protein synthesis is resistant to cycloheximide. When light and cycloheximide are presented together at various circadian phases, the final phase shift is always determined by cycloheximide. This dual-treatment phase response curve approach may be useful for other studies using pharmacological treatments to analyze clock pathways. Taken together, the results suggest that synthesis of a protein (or proteins) is involved in the photo- transduction pathway of the circadian clock in Neurospora.

Journal of Biological Rhythms, Vol. 5, No. 2, 159-167 (1990)
DOI: 10.1177/074873049000500207
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