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Chronic Clorgyline Treatment of Syrian Hamsters: An Analysis of Effects on the Circadian Pacemaker

Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20892, Department of Biological Sciences, University of Maryland, Baltimore County, Catonsville, Maryland 21228

Lawrence Tamarkin

Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20892

Phillip G. Sokolove

Department of Biological Sciences, University of Maryland, Baltimore County, Catonsville, Maryland 21228

Thomas A. Wehr

Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20892, Department of Biological Sciences, University of Maryland, Baltimore County, Catonsville, Maryland 21228

Clorgyline, a type A monoamine oxidase inhibitor with antidepressant properties when administered to depressed patients, is often associated with disturbances of the human sleep-wake cycle. In order to assess its effects on the mammalian circadian system, this drug was administered chronically to Syrian hamsters. It was found to affect the hamster circadian system in four specific ways. Clorgyline increased the intrinsic period of wheel-running ac tivity, altered the phase response curve to brief light pulses, altered the educed waveform of running activity in animals maintained in light-dark cycles or constant darkness, and in creased the activity-rest ratio in animals maintained in constant darkness. Our data support the interpretation that clorgyline exhibits direct or indirect input to the circadian pacemaker and alters the processing of photic information to the pacemaker.

Journal of Biological Rhythms, Vol. 3, No. 4, 305-322 (1988)
DOI: 10.1177/074873048800300401


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