|
Sign In to gain access to subscriptions and/or personal tools.
|
The 2008 Pittendrigh/Aschoff Lecture: Peripheral Phase Coordination in the Mammalian Circadian Timing System
Ueli Schibler
Department of Molecular Biology & NCCR Frontiers in Genetics, Sciences, University of Geneva, Geneva, Switzerland, Ueli.Schibler{at}unige.ch
The mammalian timing system is composed of a bodywide web of cell-autonomous and self-sustained oscillators. A master clock in the SCN synchronizes peripheral clocks through yet poorly understood molecular signaling pathways. In this lecture I shall present some of the experimental approaches we are employing to elucidate signaling routes through which the SCN may phase entrain peripheral clocks. These attempts unveiled several candidate pathways worth pursuing in future studies, including signaling through nuclear receptors, cytoskeleton components, Ca2+, fibroblast growth factors, ubiquitin ligases, Sirtuin 1 (a redox-sensing histone deacetylase), RNA binding proteins, and body temperature.
Key Words: peripheral clocks BMAL1 REV-ERB synchronization hepatocyte oscillators
Journal of Biological Rhythms, Vol. 24, No. 1,
3-15 (2009)
DOI: 10.1177/0748730408329383

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
This article has been cited by other articles:

|
 |

|
 |
 
J. J. Chiesa, T. Cambras, A. R. Carpentieri, and A. Diez-Noguera
Arrhythmic Rats after SCN Lesions and Constant Light Differ in Short Time Scale Regulation of Locomotor Activity
J Biol Rhythms,
February 1, 2010;
25(1):
37 - 46.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Zhang, T. J. Dube, and K. A. Esser
Working around the clock: circadian rhythms and skeletal muscle
J Appl Physiol,
November 1, 2009;
107(5):
1647 - 1654.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. L. Kilman and R. Allada
Genetic Analysis of Ectopic Circadian Clock Induction in Drosophila
J Biol Rhythms,
October 1, 2009;
24(5):
368 - 378.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
K. A. Esser and M. E. Young
The role of clock genes in cardiometabolic disease
J Appl Physiol,
October 1, 2009;
107(4):
1316 - 1317.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Oishi, D. Uchida, N. Ohkura, R. Doi, N. Ishida, K. Kadota, and S. Horie
Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1
Arterioscler Thromb Vasc Biol,
October 1, 2009;
29(10):
1571 - 1577.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|
|