Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biological Rhythms
This Article
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ciarleglio, C. M.
Right arrow Articles by Johnson, C. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ciarleglio, C. M.
Right arrow Articles by Johnson, C. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Genetic Differences in Human Circadian Clock Genes among Worldwide Populations

Christopher M. Ciarleglio

Department of Biological Sciences, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, USA

Kelli K. Ryckman

Department of Medicine and Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA

Stein V. Servick

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

Akiko Hida

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

Sam Robbins

Vanderbilt University School of Nursing, Nashville, TN, USA

Nancy Wells

Vanderbilt University School of Nursing, Nashville, TN, USA

Jennifer Hicks

Vanderbilt University School of Nursing, Nashville, TN, USA

Sydney A. Larson

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

Joshua P. Wiedermann

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

Krista Carver

Vanderbilt University School of Nursing, Nashville, TN, USA

Nalo Hamilton

Vanderbilt University School of Nursing, Nashville, TN, USA

Kenneth K. Kidd

Department of Genetics, Yale University School of Medicine, New Haven, CT, USA

Judith R. Kidd

Department of Genetics, Yale University School of Medicine, New Haven, CT, USA

Jeffrey R. Smith

Department of Medicine and Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA

Jonathan Friedlaender

Department of Biological Anthropology (emeritus), Temple University, Philadelphia, PA, USA

Douglas G. McMahon

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA

Scott M. Williams

Department of Medicine and Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA

Marshall L. Summar

Department of Pediatrics and Genetics, Vanderbilt University Medical Center, Nashville, TN, USA

Carl Hirschie Johnson

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA, carl.h.johnson{at}vanderbilt.edu

The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in photoperiod (day length) and temperature; these parameters vary dramatically as a function of latitude and locale. In wide-ranging species other than humans, natural selection has genetically optimized adaptiveness along latitudinal clines. Is there evidence for selection of clock gene alleles along latitudinal/photoperiod clines in humans? A number of polymorphisms in the human clock genes Per2, Per3, Clock, and AANAT have been reported as alleles that could be subject to selection. In addition, this investigation discovered several novel polymorphisms in the human Arntl and Arntl2 genes that may have functional impact upon the expression of these clock transcriptional factors. The frequency distribution of these clock gene polymorphisms is reported for diverse populations of African Americans, European Americans, Ghanaians, Han Chinese, and Papua New Guineans (including 5 subpopulations within Papua New Guinea). There are significant differences in the frequency distribution of clock gene alleles among these populations. Population genetic analyses indicate that these differences are likely to arise from genetic drift rather than from natural selection.

Key Words: circadian • biological clock • sleep • FASPS • depression • Arntl • Bmal • Mop • Per • Clock • AANAT

Journal of Biological Rhythms, Vol. 23, No. 4, 330-340 (2008)
DOI: 10.1177/0748730408320284
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Biol RhythmsHome page
A.-M. Chang, K. J. Reid, R. Gourineni, and P. C. Zee
Sleep Timing and Circadian Phase in Delayed Sleep Phase Syndrome
J Biol Rhythms, August 1, 2009; 24(4): 313 - 321.
[Abstract] [PDF]