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Journal of Biological Rhythms
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Modeling the Behavior of Coupled Cellular Circadian Oscillators in the Suprachiasmatic Nucleus

Premananda Indic

Department of Neurology, University of Massachusetts Medical School, Worcester, MA

William J. Schwartz

Department of Neurology, University of Massachusetts Medical School, Worcester, MA

Erik D. Herzog

Department of Biology, Washington University, St. Louis, MO

Nicholas C. Foley

Department of Cognitive and Neural Systems, Boston University, Boston, MA

Michael C. Antle

Departments of Psychology and Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta, Canada

The suprachiasmatic nucleus (SCN) in the hypothalamus is the site of the master circadian clock in mammals, a complex tissue composed of multiple, coupled, single-cell circadian oscillators. Mathematical modeling is now providing insights on how individual SCN cells might interact and assemble to create an integrated pacemaker that governs the circadian behavior of whole animals. In this article, we will discuss the neurobiological constraints for modeling SCN behavior, system precision, implications of cellular heterogeneity, and analysis of heterogeneously coupled oscillator networks. Mathematical approaches will be critical for better understanding intercellular interactions within the SCN.

Key Words: suprachiasmatic nucleus • coupled oscillators • Kuramoto model

Journal of Biological Rhythms, Vol. 22, No. 3, 211-219 (2007)
DOI: 10.1177/0748730407301238
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