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Journal of Biological Rhythms
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Circadian Rhythms in Murine Pups Develop in Absence of a Functional Maternal Circadian Clock

Corinne Jud

Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland

Urs Albrecht

Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland, urs.albrecht{at}unifr.ch

A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1Brdm1/Per2Brdm1 or mPer2Brdm1/Cry1-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic constitution for a functional circadian clock. Individual pups born to arrhythmic mPer1Brdm1/Per2Brdm1 and mPer2Brdm1/Cry1-/- mothers in constant darkness without external zeitgeber developed normal circadian rhythms, but their clocks were less synchronized to each other compared to wild-type animals. These findings indicate that development of circadian rhythms does not depend on a functional circadian clock in maternal tissue, extending previous findings obtained from pups born to SCN-lesioned mothers.

Key Words: circadian rhythm • development • synchronization • Per1 • Per2 • Cry1

Journal of Biological Rhythms, Vol. 21, No. 2, 149-154 (2006)
DOI: 10.1177/0748730406286264
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