Journal of Biological Rhythms

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to register today!

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klerman, E. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klerman, E. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Biological Rhythms, Vol. 20, No. 4, 375-386 (2005)
DOI: 10.1177/0748730405278353
© 2005 SAGE Publications

Clinical Aspects of Human Circadian Rhythms

Elizabeth B. Klerman

Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusettsebklerman{at}hms.harvard.edu

Circadian rhythmicity can be important in the pathophysiology, diagnosis, and treatment of clinical disease. Due to the difficulties in conducting the necessary experimental work, it remains unknown whether ~24-h changes in pathophysiology or symptoms of many diseases are causally linked to endogenous circadian rhythms or to other diurnal factors that change across the day, such as changes in posture, activity, sleep or wake state, or metabolic changes associated with feeding or fasting. Until the physiology is accurately known, appropriate treatment cannot be designed. This review includes an overview of clinical disorders that are caused or affected by circadian or diurnal rhythms. The clinical side effects of disruption of circadian rhythmicity, such as in shiftwork, including the public health implications of the disrupted alertness and performance, are also discussed.

Key Words: circadian rhythms • clinical disorders • clinical medicine • sleep disorders


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Biol RhythmsHome page
T. Leise and H. Siegelmann
Dynamics of a multistage circadian system.
J Biol Rhythms, August 1, 2006; 21(4): 314 - 323.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
K. Ackermann, R. Bux, U. Rub, H.-W. Korf, G. Kauert, and J. H. Stehle
Characterization of Human Melatonin Synthesis Using Autoptic Pineal Tissue
Endocrinology, July 1, 2006; 147(7): 3235 - 3242.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
J. F. Duffy and K. P. Wright Jr.
Entrainment of the Human Circadian System by Light
J Biol Rhythms, August 1, 2005; 20(4): 326 - 338.
[Abstract] [PDF]