Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biological Rhythms
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Wang, R.
Right arrow Articles by Chen, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, R.
Right arrow Articles by Chen, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Synchronizing Genetic Oscillators by Signaling Molecules

Ruiqi Wang

Department of Electrical Engineering and Electronics, Osaka Sangyo University, Osaka, Japan

Luonan Chen

Department of Electrical Engineering and Electronics, Osaka Sangyo University, Osaka, Japan, chen{at}elec.osaka-sandai.ac.jp

The authors examine collective rhythms in a general multicell system with both linearly diffusive and nondiffusive couplings. The effect of coupling on synchronization through intercellular signaling in a population of Escherichia coli cells is studied. In particular, a synchronization solution is given through the auxiliary individual system for 2 types of couplings. The sufficient conditions for the global synchronization of such a coupled system are derived based on the Lyapunov function method. The authors show that an appropriate design of the coupling and the inner-linking matrix can ensure global synchronization of the coupled synthetic biological system. Moreover, they demonstrate that the dynamics of an individual cell with coupling and without coupling may be qualitatively different; one is oscillatory, and the other is steady state. The change from a nonoscillatory state to an oscillatory one is induced by appropriate coupling, which also entrains all cells to synchronization. These results establish not only a theoretical foundation but also a quantitative basis for understanding the essential cooperative dynamics, such as collective rhythms or synchronization, in a population of cells.

Key Words: oscillation • communication • synchronization • collective rhythms • gene regulatory network • stability

Journal of Biological Rhythms, Vol. 20, No. 3, 257-269 (2005)
DOI: 10.1177/0748730405275653
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
Z. Li, S. Zhang, Y. Wang, X.-S. Zhang, and L. Chen
Alignment of molecular networks by integer quadratic programming
Bioinformatics, July 1, 2007; 23(13): 1631 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
R. Wang, L. Chen, and K. Aihara
Synchronizing a multicellular system by external input: an artificial control strategy
Bioinformatics, July 15, 2006; 22(14): 1775 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
L. Chen, R. Wang, T. Zhou, and K. Aihara
Noise-induced cooperative behavior in a multicell system
Bioinformatics, June 1, 2005; 21(11): 2722 - 2729.
[Abstract] [Full Text] [PDF]