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The tau Mutation in the Syrian Hamster Differentially Reprograms the Circadian Clock in the SCN and Peripheral Tissues
University of Manchester, Manchester, United Kingdom
University of Manchester, Manchester, United Kingdom; Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Princess Anne Hospital, Southampton, SO16 5YA, United Kingdom
University of Manchester, Manchester, United Kingdom
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
MRC Laboratory of Molecular Biology, Cambridge, United Kingdomemaywood{at}mrc-lmb.cam.ac.uk
The hypothalamic suprachiasmatic nuclei (SCN), the principal circadian oscillator in mammals, are synchronized to the solar day by the light-dark cycle, and in turn, they coordinate circadian oscillations in peripheral tissues. The tau mutation in the Syrian hamster is caused by a point mutation leading to a deficiency in the ability of Casein Kinase 1
Key Words: Period gene • PER proteins • Casein Kinase 1
Journal of Biological Rhythms, Vol. 20, No. 2,
99-110 (2005) This article has been cited by other articles:
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to phosphorylate its targets, including circadian PER proteins. How this accelerates circadian period in neural tissues is not known, nor is its impact on peripheral circadian oscillators established. We show that this mutation has no effect on per mRNA expression nor the nuclear accumulation of PER proteins in the SCN. It does, however, accelerate the clearance of PER proteins from the nucleus to an extent sufficient to explain the shortened circadian period of behavioral rhythms. The mutation also has novel, unanticipated consequences for circadian timing in the periphery, including tissue-specific phase advances and/or reduced amplitude of circadian gene expression. The results suggest that the tau mutation accelerates a specific phase, during mid-late subjective night of the SCN circadian feedback loop, rather than cause a global compression of the entire cycle. This reprogrammed output from the clock is associated with peripheral desynchrony, which in turn could account for impaired growth and metabolic efficiency of the mutant. 
