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Journal of Biological Rhythms
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Posttranscriptional and Posttranslational Regulation of Clock Genes

Emily Harms

Laboratory of Genetics, Rockefeller University, New York, NY

Saul Kivimäe

Laboratory of Genetics, Rockefeller University, New York, NY

Michael W. Young

Laboratory of Genetics, Rockefeller University, New York, NY

Lino Saez

Laboratory of Genetics, Rockefeller University, New York, NY, saez{at}rockefeller.edu

Circadian rhythms have been observed in diverse organisms, including plants, animals, bacteria, and fungi. In such organisms, the circadian clock is primarily composed of a cell-autonomous transcriptional feedback loop. In addition to transcriptional regulation, the modification of core clock transcripts and proteins can dramatically affect the circadian clock. In this review, the authors discuss some of the posttranscriptional and posttranslational modifications and their effects on the circadian clock. The combined outcome of these modifications is to adjust the timing of the clock to produce a circadian oscillator that takes approximately 24 h.

Key Words: circadian rhythms • posttranscriptional regulation • posttranslational regulation • phosphorylation • kinases • phosphatases

Journal of Biological Rhythms, Vol. 19, No. 5, 361-373 (2004)
DOI: 10.1177/0748730404268111
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