Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biological Rhythms
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Takahashi, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takahashi, J. S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Finding New Clock Components: Past and Future

Joseph S. Takahashi

Howard Hughes Medical Institute, Department of Neurobiology & Physiology, Northwestern University, Evanston, IL, j-takahashi{at}northwestern.edu

The molecular mechanism of circadian clocks has been unraveled primarily by the use of phenotype-driven (forward) genetic analysis in a number of model systems. We are now in a position to consider what constitutes a clock component, whether we can establish criteria for clock components, and whether we have found most of the primary clock components. This perspective discusses clock genes and how genetics, molecular biology, and biochemistry have been used to find clock genes in the past and how they will be used in the future.

Key Words: circadian clock components • clock genes • phenotype • forward genetics

Journal of Biological Rhythms, Vol. 19, No. 5, 339-347 (2004)
DOI: 10.1177/0748730404269151
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Genes Dev.Home page
B. Maier, S. Wendt, J. T. Vanselow, T. Wallach, S. Reischl, S. Oehmke, A. Schlosser, and A. Kramer
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock
Genes & Dev., March 15, 2009; 23(6): 708 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Hirota, W. G. Lewis, A. C. Liu, J. W. Lee, P. G. Schultz, and S. A. Kay
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3{beta}
PNAS, December 30, 2008; 105(52): 20746 - 20751.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. S. Takahashi, K. Shimomura, and V. Kumar
Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms
Science, November 7, 2008; 322(5903): 909 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
S. M. Siepka, S.-H. Yoo, J. Park, C. Lee, and J. S. Takahashi
Genetics and Neurobiology of Circadian Clocks in Mammals
Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 251 - 259.
[Abstract] [PDF]

Home page
 Hum Mol GenetHome page
C. H. Ko and J. S. Takahashi
Molecular components of the mammalian circadian clock
Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R271 - R277.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Maeda, S. Tsujiya, T. Higashide, K. Toida, T. Todo, T. Ueyama, H. Okamura, and K. Sugiyama
Circadian intraocular pressure rhythm is generated by clock genes.
Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 4050 - 4052.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
M. H. Hastings and E. D. Herzog
Clock Genes, Oscillators, and Cellular Networks in the Suprachiasmatic Nuclei
J Biol Rhythms, October 1, 2004; 19(5): 400 - 413.
[Abstract] [PDF]