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Dec1 and Dec2 Expression is Disrupted in the Suprachiasmatic Nuclei of Clock Mutant Mice

Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

Sato Honma

Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan, sathonma{at}med.hokudai.ac.jp

Tatsuya Fukumoto

Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

Takeshi Kawamoto

Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

Katsumi Fujimoto

Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

Mitsuhide Noshiro

Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

Yukio Kato

Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

Ken-Ichi Honma

Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock. The genes Dec1 and Dec2 are expressed rhythmically in the rat suprachiasmatic nuclei, and Dec1 expression is stimulated by light in a timedependent manner with the kinetics of an immediate early gene. DEC1 and DEC2 can inhibit CLOCK:BMAL1 transactivation of the clock gene Per1, suggesting that these transcription factors may help regulate circadian timing. The authors present data on the expression pattern of Dec1 and Dec2 in wild-type and homozygous Clock mutant mice. In the suprachiasmatic nuclei, the Clock mutation significantly reduces the expression of Dec1 and Dec2. Dec1 becomes arrhythmic; Dec2 remains weakly rhythmic in a 12L:12D light-dark cycle but is arrhythmic in constant darkness. A robust attenuation of the Dec1 and Dec2 signals in Clock mutant mice was detected in all brain areas examined. These data point to up-regulation of Dec1 and Dec2 by Clock in vivo.

Key Words: circadian rhythms • bHLH transcription factors • clock genes • Per1 • parietal cortex • piriform cortex

Journal of Biological Rhythms, Vol. 19, No. 2, 126-134 (2004)
DOI: 10.1177/0748730403262870


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