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Journal of Biological Rhythms
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Clean Thoughts about Dirty Genes

Russell N. van Gelder

Departments of Ophthalmology and Visual Sciences, Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, MO, vangelder{at}vision.wustl.edu

John B. Hogenesch

Genomics Institute of the Novartis Research Foundation, La Jolla, CA

The mouse has joined the fruit fly, bread mold, and cyanobacteria as a tractable genetic system for studying mechanisms of circadian rhythms. The circadian rhythms of "knock-out" mice for specific clock genes, however, have demonstrated significant variability between laboratories. In this brief review, the authors discuss possible sources of this variability, focusing particularly on questions of modifier loci of circadian rhythms that vary between inbred mouse strains. They conclude with a short list of recommendations for researchers working on circadian rhythms in mixed-strain mice.

Key Words: circadian rhythms • mouse strain • quantitative trait locus • epistasis • heterosis

Journal of Biological Rhythms, Vol. 19, No. 1, 3-9 (2004)
DOI: 10.1177/0748730403261123
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