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Journal of Biological Rhythms
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Photoperiodic Regulation of Circulating Leukocytes in Juvenile Siberian Hamsters: Mediation by Melatonin and Testosterone

Brian J. Prendergast

Department of Psychology, University of Chicago, Institute for Mind and Biology, 940 E. 57th St., Chicago, IL 60637;prendergast{at}uchicago.edu

Andrew K. Hotchkiss

Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA

Randy J. Nelson

rnelson{at}osu.edu

The reproductive system of Siberian hamsters (Phodopus sungorus) undergoes rapid phenotypic responses to changes in day length that occur around the time of weaning. The present experiments tested whether the immune system of Siberian hamsters is similarly photoperiodicearly in life and whether photoperiodic changes in melatonin or gonadal hormone secretions mediate any such responses to day length. Circulating blood leukocyte concentrations (WBC) were measured in juvenile male Siberian hamsters that were gestated in long-days (LD), transferred to short-days (SD) on the day of birth, and subsequently either remained in SD or were transferred fromSD toLDat 18 days of age (day 18). WBC values were comparable between LD and SD hamsters on day 18. Between day 18 and day 32, SD hamsters exhibited a 3-fold increase in WBC, whereas LD hamsters failed to undergo a significant increase inWBCduring this interval. WBC of LD hamsters was significantly lower than that of SD hamsters on day 25 and on day 32. In LD housed males, peripheral injections of melatonin delivered so as to extend the nocturnal duration of elevated endogenous melatonin secretion (i.e., provided in late afternoon) on days 18-31 increasedWBCas measured on day 32. Peripubertal (day 17) gonadectomy abolished the immunosuppressive effect of LD exposure on WBC, and treatment with silasticimplants containing testosterone suppressed WBC independent of photoperiod treatment. These data indicate that juvenile Siberian hamsters are immunologically responsive to photoperiod and that the leukocyte responses to day length are the result of melatonin-mediated effects of photoperiod on testicular hormone secretion.

Key Words: immune function • photoperiodism • puberty • seasonal rhythms • Phodopus sungorus

Journal of Biological Rhythms, Vol. 18, No. 6, 473-480 (2003)
DOI: 10.1177/0748730403258486
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