This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Perret, M. Articles by Schilling, A. Search for Related Content PubMed PubMed Citation Articles by Perret, M. Articles by Schilling, A. Social Bookmarking                         What's this?

Olfactory Bulbectomy Modifies Photic Entrainment and Circadian Rhythms of Body Temperature and Locomotor Activity in a Nocturnal Primate

Département d'Ecologie et Gestion de la Biodiversité, CNRS-MNHN, UMR 8571, 4 Avenue du Petit Château, 91800 France, martine.perret{at}wanadoo.fr

Fabienne Aujard

Département d'Ecologie et Gestion de la Biodiversité, CNRS-MNHN, UMR 8571, 4 Avenue du Petit Château, 91800 France

Maud Séguy

Département d'Ecologie et Gestion de la Biodiversité, CNRS-MNHN, UMR 8571, 4 Avenue du Petit château, 91800 France

Alain Schilling

Département d'Ecologie et Gestion de la Biodiversité, CNRS-MNHN, UMR 8571, 4 Avenue du Petit château, 91800 France

Studies on rodents have emphasized that removal of the olfactory bulbs modulates circadian rhythmicity. Using telemetric recordings of both body temperature (T_b) and locomotor activity (LA) in a male nocturnal primate, the gray mouse lemur, the authors investigated the effects of olfactory bulbectomy on (1) the circadian periods of T_b and LA in constant dim light condition, and (2) photic reentrainment rates of circadian rhythms following 6-h phase shifts of entrained light-dark cycle (LD 12:12). Under free-running condition, bulb-ectomized males had significantly shorter circadian periods of T_b and LA rhythms than those of control males. However, the profiles of T_b rhythms, characterized by a phase of hypothermia at the beginning of the subjective day, and T_b parameters were not modified by olfactory bulbectomy. Under a light-dark cycle, olfactory bulbectomy significantly modified the expression of daily hypothermia, especially by an increase in the latency to reach minimal daily T_b, suggesting a delayed response to induction of daily hypothermia by light onset. Re-entrainment rates following both a 6-h phase advance and a 6-h phase delay of entrained LD were also delayed in bulbectomized males. Olfactory bulbectomy led to significant fragmentation of locomotor activity and increased locomotor activity levels during the resting period. The shortening of circadian periods in bulbectomized males could partly explain the delayed responses to photic stimuli since in control males, the longer the circadian period, the better the response to light entrainment. This experiment shows for the 1st time that olfactory bulbs can markedly modify the circadian system in a primate.

Key Words: olfaction • free-running period • light-dark cycles • phase-shift • primate • Microcebus murinus

Journal of Biological Rhythms, Vol. 18, No. 5, 392-401 (2003)
DOI: 10.1177/0748730403254248


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J.-D. Li, W.-P. Hu, L. Boehmer, M. Y. Cheng, A. G. Lee, A. Jilek, J. M. Siegel, and Q.-Y. Zhou Attenuated Circadian Rhythms in Mice Lacking the Prokineticin 2 Gene. J. Neurosci., November 8, 2006; 26(45): 11615 - 11623. [Abstract] [Full Text] [PDF]