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Circadian Clock Functioning Is Linked to Acute Stress Reactivity in Rats

Centre d'Etudes des Rythmes Biologiques, School of Medicine, Hôpital Erasme, Université Libre de Bruxelles, 1070Brussels, Belgium; INRS, Laboratoryof Occupational Physiology, BP: 27, 54501 Vandoeuvre Cedex, France; weibel{at}inrs.fr

S. Maccari

Centre d'Etudes des Rythmes Biologiques, School of Medicine, Hôpital Erasme, Université Libre de Bruxelles, 1070Brussels, Belgium; 2 Laboratoire de Neuroscience du Comportement, Bat SN4 Université de Lille1, 59665 Villeneuve d'Asq, France

O. Van Reeth

Centre d'Etudes des Rythmes Biologiques, School of Medicine, Hôpital Erasme, Université Libre de Bruxelles, 1070Brussels, Belgium

At least two major physiological systems are involved in the adaptation of the organism to environmental challenges: the circadian system and the stress reaction. This study addressed thepossibility that interindividual differences in stress sensitivity and in the functioning of the circadian system are related. At 2 months of age, corticosterone secretion in response to a 20-min restraint stress was assessed in 9 Sprague-Dawley rats for which running wheel activity was recorded as a rhythmic behavioral marker of the circadian clock. Two weeks later, the adaptive response of the circadian system to an abrupt shift in the light:dark (LD) cycle was assessed in those rats using a jet-lag paradigm. Finally, after resynchronization to the new LD cycle,rats were transferred to constant darkness to assess the free-running period of their circadianrhythm of running-wheel activity. Results indicate that stress-induced corticosterone secretionwas (1) positively correlated with the number of days to resynchronize the circadian activity rhythm to the new LD cycle, and with the value of its free-running period, and (2) negatively correlated with the intensity of daily locomotor activity. Those data, emphasizing the interactions between the stress response of an organism and the functioning of its circadian system, could explain interindividual differences in humans' susceptibility to shift work or other circadian-related disorders.

Key Words: circadian clock • rhythm, stress • corticosterone • jet lag • rats

Journal of Biological Rhythms, Vol. 17, No. 5, 438-446 (2002)
DOI: 10.1177/074873002237138


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