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Journal of Biological Rhythms
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The Timing of the Human Circadian Clock Is Accurately Represented by the Core Body Temperature Rhythm following Phase Shifts to a Three-Cycle Light Stimulus Near the Critical Zone

Sat Bir S. Khalsa

Megan E. Jewett

Jeanne F. Duffy

Charles A. Czeisler

Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

Adouble-stimulus experiment was conducted to evaluate the phase of the underlying circadian clock following light-induced phase shifts of the human circadian system. Circadian phase was assayed by constant routine from the rhythm in core body temperature before and after a three-cycle bright-light stimulus applied near the estimated minimum of the core body temperature rhythm. An identical, consecutive three-cycle light stimulus was then applied, and phase was reassessed. Phase shifts to these consecutive stimuli were no different from those obtained in a previous study following light stimuli applied under steady-state conditions over a range of circadian phases similar to those at which the consecutive stimuli were applied. These data suggest that circadian phase shifts of the core body temperature rhythm in response to a three-cycle stimulus occur within 24 h following the end of the 3-day light stimulus and that this poststimulus temperature rhythm accurately reflects the timing of the underlying circadian clock.

Key Words: circadian • temperature • light • phase shift • transients • human

Journal of Biological Rhythms, Vol. 15, No. 6, 524-530 (2000)
DOI: 10.1177/074873040001500609
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