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Circadian Systems and Metabolism

Martha Merrow

Institute for Medical Psychology, Chronobiology, Goethestr. 31, D-80336 München, Germany

Circadian systems direct many metabolic parameters and, at the same time, they appear to be exquisitely shielded from metabolic variations. Although the recent decade of circadian research has brought insights into how circadian periodicity may be generated at the molecular level, little is known about the relationship between this molecular feedback loop and metabolism both at the cellular and at the organismic level. In this theoretical paper, we conjecture about the interdependence between circadian rhythmicity and metabolism. A mathematical model based on the chemical reactions of photosynthesis demonstrates that metabolism as such may generate rhythmicity in the circadian range. Two additional models look at the possible function of feedback loops outside of the circadian oscillator. These feedback loops contribute to the robustness and sustainability of circadian oscillations and to compensation for long-and short-term metabolic variations. The specific circadian property of temperature compensation is put into the context of metabolism. As such, it represents a general compensatory mechanism that shields the clock from metabolic variations.

Key Words: oscillator models • circadian system • metabolic feedbacks • temperature compensation

Journal of Biological Rhythms, Vol. 14, No. 6, 449-459 (1999)
DOI: 10.1177/074873099129001019


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