|
Sign In to gain access to subscriptions and/or personal tools.
|
Melatonin Rhythms in Delayed Sleep Phase Syndrome
Kayo Shibui
Makoto Uchiyama
Masako Okawa
Department of Psychophysiology, National Institute of Mental Health National Center of Neurology and Psychiatry, Chiba, Japan
The aim of this study was to compare circadian and sleep characteristics between patients with delayed sleep phase syndrome (DSPS) and healthy controls. The authors studied 8 DSPS patients and 15 normal controls. Serum melatonin concentration was assessed every hour for 24 h under dim light conditions. The sleep phase and the melatonin rhythm in DSPS patients were significantly delayed compared to those in normal controls. Sleep length was significantly greater in DSPS patients compared to that in controls, but the duration of melatonin secretion did not differ between the two groups. The final awakening, relative to melatonin onset, melatonin midpoint, and melatonin offset, was significantly longer in DSPS patients than in controls. By contrast, the timing of sleep onset relative to melatonin rhythm did not differ between the two groups. The authors found a significant positive correlation between sleep phase markers and melatonin phase markers in DSPS. They postulate that a delayed circadian pacemaker may be responsible for delayed sleep phase syndrome. The alteration of phase angle between melatonin rhythm and sleep phase suggested that not only the delay of the circadian clock but also a functional disturbance of the sleep-wake mechanism underlies DSPS.
Key Words: sleep disorder • delayed sleep phase syndrome • DSPS • melatonin • circadian rhythm • light
Journal of Biological Rhythms, Vol. 14, No. 1,
72-76 (1999)
DOI: 10.1177/074873049901400110
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A.-M. Chang, K. J. Reid, R. Gourineni, and P. C. Zee
Sleep Timing and Circadian Phase in Delayed Sleep Phase Syndrome
J Biol Rhythms,
August 1, 2009;
24(4):
313 - 321.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. C. Zee
Circadian Rhythm Sleep Disorders
ACCP Sleep Med Brd Rev,
January 1, 2009;
4(0):
63 - 76.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S.-F. Gau, C.-Y. Shang, K. R. Merikangas, Y.-N. Chiu, W.-T. Soong, and A. T.-A. Cheng
Association between Morningness-Eveningness and Behavioral/Emotional Problems among Adolescents
J Biol Rhythms,
June 1, 2007;
22(3):
268 - 274.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Ayalon, K. Borodkin, L. Dishon, H. Kanety, and Y. Dagan
Circadian rhythm sleep disorders following mild traumatic brain injury
Neurology,
April 3, 2007;
68(14):
1136 - 1140.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. Millman and Working Group on Sleepiness in Adolescents/Young A
Excessive Sleepiness in Adolescents and Young Adults: Causes, Consequences, and Treatment Strategies
Pediatrics,
June 1, 2005;
115(6):
1774 - 1786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Mongrain, S. Lavoie, B. Selmaoui, J. Paquet, and M. Dumont
Phase Relationships between Sleep-Wake Cycle and Underlying Circadian Rhythms in Morningness-Eveningness
J Biol Rhythms,
June 1, 2004;
19(3):
248 - 257.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.-J. Dijk and S. W. Lockley
Functional Genomics of Sleep and Circadian Rhythm: Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity
J Appl Physiol,
February 1, 2002;
92(2):
852 - 862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Cole, J. S. Smith, Y. C. Alcal, J. A. Elliott, and D. F. Kripke
Bright-Light Mask Treatment of Delayed Sleep Phase Syndrome
J Biol Rhythms,
February 1, 2002;
17(1):
89 - 101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M F P Peres, M S. del Rio, M L V Seabra, S Tufik, J Abucham, J Cipolla-Neto, S D Silberstein, and E Zukerman
Hypothalamic involvement in chronic migraine
J. Neurol. Neurosurg. Psychiatry,
December 1, 2001;
71(6):
747 - 751.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
