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Melatonin Chimeras Alter Reproductive Development and Photorefractoriness in Siberian Hamsters

Departments of Psychology; University of California, Berkeley, CA 94720

Irving Zucker

Departments of Psychology, Integrative Biology; University of California, Berkeley, CA 94720

Steven M. Yellon

Center for Perinatal Biology, Departments of Psychology; Loma Linda University School of Medicine, Loma Linda, CA 92350

Daniel A. Ringold

Departments of Psychology; University of California, Berkeley, CA 94720

Michael R. Gorman

Department of Psychology; University of Michigan, Ann Arbor, MI 48109

Nightly melatonin (MEL) durations > 8 h provoke gonadal regression and decreases in body mass, whereas signals < 7 h stimulate gonadal and somatic growth in male Siberian hamsters. The authors sought to determine the minimum frequency of short MEL signals sufficient to induce the long-day phenotype in several photoperiodic traits. D,L-propranolol (hereafter propranolol) injections shortened MEL signals on the night of treatment without altering MEL on the subsequent night; this permitted interpolation of short MEL signals at variable frequencies against a background of long MEL signals (chimeras). Hamsters kept in short days (10 h light/day, 10L) were injected with propranolol 6 h after dark onset for 28 consecutive weeks beginning at 30 days of age (Week 0) either every other day or once every 3, 6, or 9 days. Control animals were injected with saline or with propranolol during the light phase or were transferred to long days (16L) at Week 0. Hamsters in 16L underwent rapid gonadal development and increases in body mass and displayed summer pelage color, as did hamsters treated with propranolol every other day. Animals treated with propranolol less frequently than every other day uniformly maintained undeveloped gonads and winter-like body weights, but pelage color becameproportionately darker with increased frequency of propranolol treatments. The onset of spontaneous testicular development in 10L was unaffected by propranolol injections. After termination of injections at Week 28, testicular regression was not observed in most 10L animals that previously had undergone spontaneous testicular development; however, 40% of hamsters that had been injected with propranolol every 3rd night did manifest the winter phenotype after Week 28. In an alternating sequence, short MEL signals completely override long signals and induce the summer phenotype. Threshold frequencies differ for MEL stimulation of long-day pelage and gonadal phenotypes. The timing and development of refractoriness to MEL does not depend in any simple manner on the number of long MEL signals or on the accumulation of a reaction product produced by long, and depleted by short, MEL signals.

Key Words: melatonin • Phodopus sungorus • reproduction • FSH • photoperiodism • D • L-propranolol

Journal of Biological Rhythms, Vol. 13, No. 6, 518-531 (1998)
DOI: 10.1177/074873098129000345


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