This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Davidson, A. J. Articles by Stephan, F. K. Search for Related Content PubMed PubMed Citation Articles by Davidson, A. J. Articles by Stephan, F. K. Social Bookmarking                         What's this?

Circadian Food Anticipation Persists in Capsaicin Deafferented Rats

Friedrich K. Stephan

Neuroscience Program, Department of Psychology, Florida State University, Tallahassee, FL 32306-1270

The feeding-entrained circadian oscillator (FEO) organizes locomotor activity and other variables to anticipate daily timed meals. Whether the biological substrate for the FEO is in the central nervous system or in the periphery, there must be communication between the gut and the brain to result in a behavioral output. To investigate potential neural routes of communication, rats with suprachiasmatic lesions were given systemic capsaicin (total dose: 100 mg/kg, ip) to produce visceral deafferentation. Deafferentation was confirmed using the phenyl-p-benzoquinone stretch test and the corneal irritation test. A 3-h meal was made available at the same time each day while wheel running was recorded for several weeks. Results indicated that rats with capsaicin lesions were somewhat more active overall and during nonanticipation times, but the onset time and the amount of anticipatory wheel running did not differ from vehicle-treated controls. In addition, reentrainment following a phase delay of mealtime and the persistence of anticipatory activity during food deprivation were similar between the groups. Since capsaicin deafferentation and subdiaphragmatic vagotomy do not prevent food-anticipatory activity, it is likely that communication between the gut and the brain is accomplished via a humoral route.

Key Words: circadian • feeding • entrainment • capsaicin • deafferentation • anticipatory activity

Journal of Biological Rhythms, Vol. 13, No. 5, 422-429 (1998)
DOI: 10.1177/074873049801300507


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. LeSauter, N. Hoque, M. Weintraub, D. W. Pfaff, and R. Silver Stomach ghrelin-secreting cells as food-entrainable circadian clocks PNAS, August 11, 2009; 106(32): 13582 - 13587. [Abstract] [Full Text] [PDF]

				C. B. Saper and P. M. Fuller Inducible Clocks: Living in an Unpredictable World Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 543 - 550. [Abstract] [PDF]

				G. J. Landry, M. M. Simon, I. C. Webb, and R. E. Mistlberger Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1527 - R1534. [Abstract] [Full Text] [PDF]

				M. Angeles-Castellanos, J. Mendoza, M. Diaz-Munoz, and C. Escobar Food entrainment modifies the c-Fos expression pattern in brain stem nuclei of rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R678 - R684. [Abstract] [Full Text] [PDF]

				M. J. Paul, A. S. Kauffman, and I. Zucker Feeding Schedule Controls Circadian Timing of Daily Torpor in SCN-Ablated Siberian Hamsters J Biol Rhythms, June 1, 2004; 19(3): 226 - 237. [Abstract] [PDF]

				F. K. Stephan The "Other" Circadian System: Food as a Zeitgeber J Biol Rhythms, August 1, 2002; 17(4): 284 - 292. [Abstract] [PDF]

				B. J. Aragona, J. T. Curtis, A. J. Davidson, Z. Wang, and F. K. Stephan Behavioral and Neurochemical Investigation of Circadian Time-Place Learning in the Rat J Biol Rhythms, August 1, 2002; 17(4): 330 - 344. [Abstract] [PDF]

				M. Diaz-Munoz, O. Vazquez-Martinez, R. Aguilar-Roblero, and C. Escobar Anticipatory changes in liver metabolism and entrainment of insulin, glucagon, and corticosterone in food-restricted rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2048 - R2056. [Abstract] [Full Text] [PDF]

				A. J. Davidson, S. L. T. Cappendijk, and F. K. Stephan Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1296 - R1304. [Abstract] [Full Text] [PDF]

				A. J. Davidson and F. K. Stephan Feeding-entrained circadian rhythms in hypophysectomized rats with suprachiasmatic nucleus lesions Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1376 - R1384. [Abstract] [Full Text] [PDF]