This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Oklejewicz, M. Articles by Stirland, A. J. Search for Related Content PubMed PubMed Citation Articles by Oklejewicz, M. Articles by Stirland, A. J. Social Bookmarking                         What's this?

Metabolic Rate Changes Proportionally to Circadian Frequency in tau Mutant Syrian Hamsters

Zoological Laboratory, University of Groningen, 9750 AA Haren, the Netherlands

Roelof A. Hut

Zoological Laboratory, University of Groningen, 9750 AA Haren, the Netherlands

Serge Daan

Zoological Laboratory, University of Groningen, 9750 AA Haren, the Netherlands

Andrew S. I. Loudon

School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom

Anne J. Stirland

School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom

The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S⁺). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in energy metabolism. In hamsters of the three genotypes (SS, S⁺, and wild type [WT]), oxygen consumption measurements were performed at 28°C (thermoneutral), 18°C, and (after acclimatization) 10°C. After correction for body mass, SS tau mutant hamsters had a higher overall metabolic rate (average oxygen consumption per hour over 24 h) and a higher resting metabolic rate (the lowest 30-min oxygen consumption in the subjective day) than did WT hamsters at all ambient temperatures. S ⁺ hamsters were intermediate in both after taking body mass into account. The differences in metabolism among the three genotypes indicate that the increase in metabolic rate was statistically indistinguishable from a proportional increase in circadian frequency. The oxygen consumption totals per circadian cycle (24 h for WT, 22 h for S⁺, and 20 h for SS mutants) were not statistically different among the genotypes after correcting for body mass. The possible roles of pleiotropic effects, of linkage to genes involved in growth and metabolism, and of early ontogenetic influences are briefly discussed.

Key Words: hamster • circadian mutation • tau • metabolism • resting metabolic rate

Journal of Biological Rhythms, Vol. 12, No. 5, 413-422 (1997)
DOI: 10.1177/074873049701200503


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. A. Schubert, L. M. Vaanholt, F. Stavasius, G. E. Demas, S. Daan, and G. H. Visser Female mice respond differently to costly foraging versus food restriction J. Exp. Biol., July 15, 2008; 211(14): 2214 - 2223. [Abstract] [Full Text] [PDF]

				L. M. Vaanholt, B. De Jong, T. Garland Jr, S. Daan, and G. H. Visser Behavioural and physiological responses to increased foraging effort in male mice J. Exp. Biol., June 1, 2007; 210(11): 2013 - 2024. [Abstract] [Full Text] [PDF]

				A.S.I. Loudon, Q.J. Meng, E.S. Maywood, D.A. Bechtold, R.P. Boot-Handford, and M.H. Hastings The Biology of the Circadian Ck1{epsilon} tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 261 - 271. [Abstract] [PDF]

				J. Dey, A.-J. F. Carr, F. R. A. Cagampang, A. S. Semikhodskii, A. S. I. Loudon, M. H. Hastings, and E. S. Maywood The tau Mutation in the Syrian Hamster Differentially Reprograms the Circadian Clock in the SCN and Peripheral Tissues J Biol Rhythms, April 1, 2005; 20(2): 99 - 110. [Abstract] [PDF]

				P. Koteja Jr., J. G. Swallow, P. A. Carter, and T. Garland Different Effects of Intensity and Duration of Locomotor Activity on Circadian Period J Biol Rhythms, December 1, 2003; 18(6): 491 - 501. [Abstract] [PDF]

				M. Oklejewicz and S. Daan Enhanced Longevity in Tau Mutant Syrian Hamsters, Mesocricetus auratus J Biol Rhythms, June 1, 2002; 17(3): 210 - 216. [Abstract] [PDF]

				A. Klarsfeld and F. Rouyer Effects of Circadian Mutations and LD Periodicity on the Life Span of Drosophila melanogaster J Biol Rhythms, December 1, 1998; 13(6): 471 - 478. [Abstract] [PDF]