Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Journal of Biological Rhythms
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Melo, L.
Right arrow Articles by Ralph, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Melo, L.
Right arrow Articles by Ralph, M. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Regulation of Circadian Photic Responses by Nitric Oxide

Lucy Melo

Department of Zoology

Diego A. Golombek

Departamento de Fisiologia, Facultad de Medicina, University of Buenos Aires, Argentina

Martin R. Ralph

Department of Zoology, Psychology

A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO -, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selec tively attenuated phase advances of locomotor rhythms and had no effect on phase delays. The NO- donor, SNAP, potentiated both photic responses, and phase delays were larger than the maximum responses that could be obtained with light alone. The data suggest a model in which NO- participates in the adaptation of the system to environmental lighting conditions by regulating in a phase-dependent manner responsiveness to light.

Key Words: nitric oxide • circadian rhythms • phase shifting • cyclic GMP

Journal of Biological Rhythms, Vol. 12, No. 4, 319-326 (1997)
DOI: 10.1177/074873049701200404
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
P. V. Agostino, S. A. Plano, and D. A. Golombek
Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules
PNAS, June 5, 2007; 104(23): 9834 - 9839.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. A. Ferreyra and D. A. Golombek
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1348 - R1355.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
L. J. Kriegsfeld, G. E. Demas, S. E. Lee Jr., T. M. Dawson, V. L. Dawson, and R. J. Nelson
Circadian Locomotor Analysis of Male Mice Lacking the Gene for Neuronal Nitric Oxide Synthase (nNOS-/-)
J Biol Rhythms, February 1, 1999; 14(1): 20 - 27.
[Abstract] [PDF]