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Journal of Biological Rhythms
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Regulation of Circadian Photic Responses by Nitric Oxide

Lucy Melo

Department of Zoology

Diego A. Golombek

Departamento de Fisiologia, Facultad de Medicina, University of Buenos Aires, Argentina

Martin R. Ralph

Department of Zoology, Psychology

A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO -, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selec tively attenuated phase advances of locomotor rhythms and had no effect on phase delays. The NO- donor, SNAP, potentiated both photic responses, and phase delays were larger than the maximum responses that could be obtained with light alone. The data suggest a model in which NO- participates in the adaptation of the system to environmental lighting conditions by regulating in a phase-dependent manner responsiveness to light.

Key Words: nitric oxide • circadian rhythms • phase shifting • cyclic GMP

Journal of Biological Rhythms, Vol. 12, No. 4, 319-326 (1997)
DOI: 10.1177/074873049701200404
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