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Suprachiasmatic Nuclei Lesions Do Not Eliminate Homeostatic Thermoregulatory Responses in Rats

Department of Psychology, University of Delaware, Newark, DE 19716

Hua Li

Department of Psychology, University of Delaware, Newark, DE 19716

Hideto Tanaka

Department of Psychology, University of Delaware, Newark, DE 19716

Elizabeth Peloso

Department of Psychology, University of Delaware, Newark, DE 19716

Evelyn Satinoff

Department of Psychology, University of Delaware, Newark, DE 19716

Electrolytic lesions aimed at the suprachiasmatic nuclei (SCN) were made in male Long-Evans rats. Body temperature (Tb), activity, and drinking were monitored continuously in a 12-h light:12-h dark (12:12 LD) cycle at an ambient temperature of 23°C. Large SCN lesions eliminated activity and drink ing rhythms and abolished or reduced the circadian rhythm of Tb. The Tb responses of the rats were measured in L after exposure to cold and injection of lipopolysaccharide (LPS), a fever-producing drug, and in both L and D during a 30-min exposure to a novel cage. Rats with SCN lesions (SCNX) maintained their Tb as well as did controls during 2-h exposure to 2°C. They also showed the expected increases in Tb in response to novelty and LPS. Nevertheless, there were differences between SCNX rats and other rats. When measured 9 h after LPS injection, SCNX rats had lower Tb in D than did sham-lesioned or intact rats or rats with lesions that missed the SCN. This is not surprising; the Tb of SCNX rats does not go as high as that of intact rats in D. However, it was surprising that at night SCNX rats increased their Tb in response to novelty (lights on in the test situation), whereas normal rats did not. For some reason, light inhibits the Tb rise to novelty in normal rats but does not do so in rats with SCN lesions.

Key Words: suprachiasmatic nuclei lesion • circadian rhythms • temperature regulation • novelty • fever • rats

Journal of Biological Rhythms, Vol. 12, No. 3, 226-234 (1997)
DOI: 10.1177/074873049701200304


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