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Journal of Biological Rhythms, Vol. 12, No. 3,
204-217 (1997)
DOI: 10.1177/074873049701200302
Quantitative Analysis of Drosophila period Gene Transcription in Living Animals
Jeffrey D. Plautz
Department of Biology and NSF Center for Biological Timing, University of Virginia, Charlottesville, VA 22903
Martin Straume
NSF Center for Biological Timing and Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908
Ralf Stanewsky
Department of Biology and NSF Center for Biological Timing, Brandeis University, Waltham, MA 02254
Creston F. Jamison
Department of Biology and NSF Center for Biological Timing, Brandeis University, Waltham, MA 02254
Christian Brandes
Department of Biology and NSF Center for Biological Timing, Brandeis University, Waltham, MA 02254
Harold B. Dowse
Department of Zoology, Murray Hall, University of Maine, Orono, ME 04469
Jeffrey C. Hall
Department of Biology and NSF Center for Biological Timing, Brandeis University, Waltham, MA 02254
Steve A. Kay
Department of Biology and NSF Center for Biological Timing, University of Virginia, Charlottesville, VA 22903
To determine the in vivo regulatory pattern of the clock gene period (per), the authors recently developed transgenic Drosophila carrying a luciferase cDNA fused to the promoter region of per. They have now carried out noninvasive, high time-resolution experiments allowing high-throughput monitoring of circadian bioluminescence rhythms in individual living adults for several days. This immediately solved several problems (resulting directly from individual asyn chrony within a population) that have accompanied previous biochemical ex periments in which groups of animals were sacrificed at each time point. Furthermore, the authors have developed numerical analysis methods for auto matically determining rhythmicity associated with bioluminescence records from single flies. This has revealed some features of per gene transcription that were previously unappreciated and provides a general strategy for the analysis of rhythmic time series in the study of molecular rhythms.
Key Words: Drosophila • period gene • circadian clock • luciferase • automated rhythm analysis
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