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Two Distinct Retinal Projections to the Hamster Suprachiasmatic Nucleus

Department of Physiology and Biophysics, State University of Leiden, 2300 RC, Leiden, Netherlands and Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1

H. Abe

Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1

B. Rusak

Department of Psychology and Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1

D.M. Goguen

Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1

Electrical stimulation of the intergeniculate leaflet (IGL) region in ham sters can induce expression of Fos-like immunoreactivity (lir) in a restricted portion of the dorsolateral suprachiasmatic nucleus (SCN). The authors investi gated whether the mechanisms by which stimulation affects SCN cells involves orthodromic activation of IGL cells projecting to the SCN or antidromic activa tion of retinal ganglion cells that send bifurcating axonal projections to both the IGL and the SCN. Bilateral optic enucleation strongly reduced induction of Fos-lir in SCN cells in response to electrical stimulation of the IGL region, implicating antidromic activation of retinal ganglion cells as the mechanism. This result implies that a class of retinal ganglion cells that project to the IGL also project selectively to the dorsolateral SCN. Earlier pharmacological studies suggest that this anatomically distinct retinal projection to the SCN is also neurochemically different from that innervating the rest of the nucleus.

Key Words: retinohypothalamic tract • geniculohypothalamic tract • immediate-early gene • hamster • Fos • immunoreactivity • suprachiasmatic nucleus • antidromic activation • retinal ganglion cell • electrical stimulation

Journal of Biological Rhythms, Vol. 10, No. 4, 299-307 (1995)
DOI: 10.1177/074873049501000403


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